H2N2V1, France, Analysis, bibRecord, 000235

Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells.

Identifieur interne : 000235 ( France/Analysis ); précédent : 000234; suivant : 000236

Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells.

Auteurs : Karine Labadie [France] ; Emmanuel Dos Santos Afonso [France] ; Marie-Anne Rameix-Welti [France] ; Sylvie Van Der Werf [France] ; Nadia Naffakh [France]

Source :

Virology [ 0042-6822 ] ; 2007-06-05.

RBID : Hal:hal-00167811

Abstract

The transcription/replication activity of ribonucleoproteins derived from influenza A primary isolates of human (A/Paris/908/97) or avian origin (A/Mallard/Marquenterre/MZ237/83, A/Hong Kong/156/97) was compared upon reconstitution in mammalian or avian cells, using viral-like reporter RNAs synthesized under the control of the human and chicken RNA polymerase I promoters, respectively. In avian cells, transcription/replication activities were in the same range with all ribonucleoproteins tested. In human cells, ribonucleoproteins derived from A/Mallard/Marquenterre/MZ237/83 showed reduced transcription/replication activity and reduced NP binding to the PB1-PB2-PA complex (P) or to the isolated PB2 subunit, as compared to the ribonucleoproteins derived from A/Paris/908/97. Both defects were restored when PB2 residue Glu-627 was changed to a Lys. Ribonucleoproteins derived from the human A/Hong Kong/156/97 H5N1 isolate showed efficient NP-P interaction in human cells, and high levels of activity which were determined mostly by the PB2 and PA proteins. Our data suggest that PB2 might play a pivotal role in molecular interactions involving both the viral nucleoprotein and cellular proteins.

Url:

https://hal.archives-ouvertes.fr/hal-00167811

DOI: 10.1016/j.virol.2006.12.027

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000136
to stream Hal, to step Curation: 000136
to stream Hal, to step Checkpoint: 000316
to stream Main, to step Merge: 001365
to stream Main, to step Curation: 001352
to stream Main, to step Exploration: 001352
to stream France, to step Extraction: 000235

Links to Exploration step

Hal:hal-00167811

Le document en format XML

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<tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD">          <idno type="ISNI">0000000121514068</idno>
          <idno type="IdRef">027542084</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="URA1966" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-31889" status="OLD">          <orgName>Génétique Moléculaire des Virus Respiratoires</orgName>
          <desc>            <address>              <addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
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            <relation active="#struct-300301" type="direct"></relation>
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        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD">          <idno type="ISNI">0000000121514068</idno>
          <idno type="IdRef">027542084</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="URA1966" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-31889" status="OLD">          <orgName>Génétique Moléculaire des Virus Respiratoires</orgName>
          <desc>            <address>              <addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
            <relation active="#struct-300301" type="direct"></relation>
            <relation name="URA1966" active="#struct-441569" type="direct"></relation>
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          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD">          <idno type="ISNI">0000000121514068</idno>
          <idno type="IdRef">027542084</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="URA1966" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.virol.2006.12.027</idno>
<series><title level="j">Virology</title>
<idno type="ISSN">0042-6822</idno>
<imprint><date type="datePub">2007-06-05</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>The transcription/replication activity of ribonucleoproteins derived from influenza A primary isolates of human (A/Paris/908/97) or avian origin (A/Mallard/Marquenterre/MZ237/83, A/Hong Kong/156/97) was compared upon reconstitution in mammalian or avian cells, using viral-like reporter RNAs synthesized under the control of the human and chicken RNA polymerase I promoters, respectively. In avian cells, transcription/replication activities were in the same range with all ribonucleoproteins tested. In human cells, ribonucleoproteins derived from A/Mallard/Marquenterre/MZ237/83 showed reduced transcription/replication activity and reduced NP binding to the PB1-PB2-PA complex (P) or to the isolated PB2 subunit, as compared to the ribonucleoproteins derived from A/Paris/908/97. Both defects were restored when PB2 residue Glu-627 was changed to a Lys. Ribonucleoproteins derived from the human A/Hong Kong/156/97 H5N1 isolate showed efficient NP-P interaction in human cells, and high levels of activity which were determined mostly by the PB2 and PA proteins. Our data suggest that PB2 might play a pivotal role in molecular interactions involving both the viral nucleoprotein and cellular proteins.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Labadie, Karine" sort="Labadie, Karine" uniqKey="Labadie K" first="Karine" last="Labadie">Karine Labadie</name>
</noRegion>
<name sortKey="Dos Santos Afonso, Emmanuel" sort="Dos Santos Afonso, Emmanuel" uniqKey="Dos Santos Afonso E" first="Emmanuel" last="Dos Santos Afonso">Emmanuel Dos Santos Afonso</name>
<name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name>
<name sortKey="Rameix Welti, Marie Anne" sort="Rameix Welti, Marie Anne" uniqKey="Rameix Welti M" first="Marie-Anne" last="Rameix-Welti">Marie-Anne Rameix-Welti</name>
<name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells.
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Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells.

Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells.

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